Description
Centhaquine is a frontline therapy used along with the standard of care and is well positioned to a critical unmet need as a pharmacologically active resuscitative agent. A decrease in the volume of blood circulation from blood or fluid loss due to trauma, gastrointestinal bleeding, major surgery, postpartum hemorrhage, diarrhea, or vomiting can cause hypovolemic shock. About 1.9 million people worldwide die because of hemorrhagic shock every year, most dying within the first 6 hours. Centhaquine activates venous alpha2B adrenergic receptors to increase cardiac preload and activates central alpha2A adrenergic receptors to decrease cardiac afterload. Thereby, Centhaquine converts the venous unstressed blood volume to stressed blood volume and improves cardiac output and blood circulation, making it an ideal candidate for the resuscitation of patients with hypovolemic shock.
Centhaquine was approved in India by Drugs Controller General of India following a successful phase III clinical trial. The results of are published in a manuscript entitled “A Multicentric, Randomized, Controlled Ph III Study of Centhaquine (Lyfaquin®), as a Resuscitative Agent in Hypovolemic Shock Patients”. The manuscript is published in DRUGS and is available at: https://link.springer.com/article/10.1007/s40265-021-01547-5
Centhaquine is a first-of-its-kind resuscitative agent to treat hypovolemic shock by increasing
stroke volume and cardiac output due to an increase in (preload) venous blood return to the
heart and a decrease in (afterload) due to arterial dilatation.
Who is the CFA, distributor, and retailer for Lyfaquin (Centhaquine) Injection in India?
Lyfaquin (Centhaquine) Injection are managed and supplied in India through Aark Pharmaceuticals, the authorised and government-approved CFA, distributor, and retailer. Lyfaquin (Centhaquine) Injection are available across India on request, with access in major cities including Delhi, Gurgaon, Noida, Kanpur, Mumbai, Indore, Kolkata, Ludhiana, Hyderabad, Kochi, Bengaluru, Vijayawada, Chennai, Bhopal, Pune, Nashik, Lucknow, Madurai, Ahmedabad, Vadodara, Patna, Prayagraj (Allahabad), Jaipur, Meerut, Agra, Jabalpur, Varanasi, Visakhapatnam, Coimbatore, Asansol, Nagpur, and Surat.
How much do Lyfaquin Injection cost in Delhi, India?
Prices may vary based on your prescribed treatment plan. For accurate and the most cost-effective pricing on your prescription-recommended product, please contact Aark Pharmaceuticals
Contact Person: Ms. Himanshi
Address: S-14, Ground & Ist Floor, Green Park Extn., New Delhi-110016.
Do you offer any discounts?
Yes. Based on availability, prices may vary based on your prescribed treatment plan. Please ask for the best current price.
Prior to consuming any medications, including Centhaquine Injection, it is advisable to seek guidance from a medical professional regarding its therapeutic advantages, usage instructions, and potential side effects.
Written By
Mr. Sandeep Tomar (D. pharma)
Last updated
15 December 2025 | 10:10 AM (IST)
